Comparison of small molecule inhibitors of poly(ADP)ribose polymerase-1 and DNA-dependent protein kinase as radiosensitizers of head and neck squamous cell carcinoma cell lines

lee_et_al_radiosensitizer_regrowth_data.tsv: Two PARP1 inhibitors (olaparib, veliparib) and two DNA-PK inhibitors (KU57788, IC87361) were tested in 14 HNSCC cell lines, as well as HEK-293 and WI-38/Va-13 cell lines, with drug exposure for 6 or 24 h post-irradiation, using regrowth assays. Full data set including regrowth fractions, total enhancement ratios and sensitizer enhancement ratios, for each cell line, inhibitor concentration, and experiment are in this file.lee_et_al_analyse_tcga_hnsc_slfn11.zip: Contains R code and required intermediate data for performing analysis of SLFN11 expression in TCGA HNSC cohort.

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CC BY 4.0

Data and Resources

Additional Info

Field Value
Theme
Author Tet Woo Lee (1218699), Way Wong (1220982), Benjamin Dickson (1184676), Barbara Lipert (4077031), Francis Hunter (1192173), Michael Hay (1205496), William Wilson (1220967)
Maintainer
Source https://figshare.com/articles/dataset/Comparison_of_small_molecule_inhibitors_of_poly_ADP_ribose_polymerase-1_and_DNA-dependent_protein_kinase_as_radiosensitizers_of_head_and_neck_squamous_cell_carcinoma_cell_lines/7890455
Source Created 2019-03-27T01:40:09Z
Source Modified 2019-03-27T01:40:09
Language English
Spatial
Source Identifier 10.17608/k6.auckland.7890455.v3
Dataset metadata created 1 August 2019, last updated 2 April 2025